Effects of yeast hydrolysate on hepatic lipid metabolism in high-fat-diet-induced obese mice: yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis.

The effects of yeast hydrolysate on body fat accumulation.


Written by Jung EY, Hong YH, Kim JH, Park Y, Bae SH, Chang UJ, Suh HJ

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We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Male ICR mice were divided into four groups: a normal diet group (ND; 4.2% fat), a high-fat diet group (HF; 27.7% fat), an HF group treated orally with 0.5% or 1% YH in the drinking water (HF+YH0.5; 27.7% fat and HF+YH1; 27.7% fat). After 5 weeks, the YH groups (HF+YH0.5 = 3.92 ± 0.17 g/100 g BW and HF+YH1 = 3.76 ± 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 ± 0.29 g/100 g BW; p < 0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p < 0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 ± 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 ± 2.23 nmol/min/mg protein; p < 0.05). YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities.