Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles
The effects of vitamin D induced by high fat diet on obesity.
In summary, the present study demonstrates that the regulation energy metabolism, which was hypothesized to be directly acted on by 1,25(OH)2VD3, involves UCP3 via VDR. Furthermore, UCP3 and VDR is expressed widely throughout the skeletal muscle in the whole body. This suggests that circulating 1,25(OH)2VD3 are related to the direct effects of local thermogenesis and energy metabolism.